Dating klinefelter wapxxx com3gp
All features thus far examined in these animals show, as good as possible in an animal model, a close resemblance to those of the human disorder.
Although further studies are still needed to determine whether these animals have comparable metabolic changes to those seen in patients (e.g.
When, due to meiotic non-disjunction events, males are born with a supernumerary X chromosome, the resulting 47, XXY karyotype is referred to as Klinefelter's syndrome.
This frequent genetic condition is most commonly associated with infertility, hypogonadism, gynecomastia and cognitive impairments.
., 1991; Hunt and Eicher 1991).(A) Animals were obtained from the B6Ei. The spontaneously mutated male mice carried a Y chromosome, designated Y*, which acquired a new centromere distally and lost the normal centromere.
(B) Breeding such phenotypically normal and fertile 40, XY* males to 40, XX females provoked sex chromosomal non-disjunction events during meiosis and result in ∼25% of the male offspring exhibiting the 41, XX* karyotype.
The elucidation of the detrimental mechanisms which are driven by the supernumerary X chromosome requires experimental approaches that are limited in humans because of ethical implications.